Unprecedented $100 Million From Susan G. Komen for the Cure(R) Committed to Immediate Patient Help

Leader of Global Breast Cancer Movement Takes New Approach to Research, Focuses on Delivering Cures to Patients Sooner

Unprecedented $100 Million From Susan G. Komen for the Cure(R) Committed to Immediate Patient Help

DALLAS, Sept. 30 /PRNewswire/ -- Determined to fast track research into help for breast cancer patients who can't wait, Susan G. Komen for the Cure(R) is distributing an unprecedented $100 million in grants to American and international scientists this year alone, the organization announced in unveiling its 2008 grants portfolio today.

(Logo: http://www.newscom.com/cgi-bin/prnh/20070122/NYM084LOGO)

It is the largest commitment of breast cancer research funding by a single nonprofit organization, targeted to 81 universities and hospitals in 27 states and five countries. These grants represent research with the highest likelihood of producing results for patients during the next decade.

"There's a tremendous urgency to translate what we're learning in the lab into treatments for patients, particularly patients with very aggressive cancers who don't have years to wait," said Dr. Eric P. Winer, chief scientific advisor to Susan G. Komen for the Cure and director of the Breast Oncology Center at Dana-Farber Cancer Institute.

"The grants we are funding focus on safely and effectively bringing treatments to cancer patients in a more timely way than we have been able to in the past," Winer added.

"We've revamped Komen's research program, challenging the best minds to solve the most difficult issues in breast cancer," said Hala Moddelmog, president and CEO of Susan G. Komen for the Cure. "These grants are geared to results -- finding cures, tailoring treatments and resolving the issues that have stymied the search for a breast cancer cure."

Some of the biggest questions to be tackled by the Komen-funded research include:

    -- Why do some breast cancers respond to certain treatments, and others
       don't?
    -- How can we prevent the spread of breast cancer to other organs?
    -- Does diet and/or obesity play a role in cancer development and
       treatment?
    -- Can we predict who is most at risk for developing breast cancer?
    -- Can we develop a cancer vaccine?
    -- What technologies will help detect breast cancer at its earliest
       possible stage?
    -- What treatments can prolong the lives of those women living with
       advanced breast cancer?

During the past 25 years, Komen for the Cure has raised and distributed $1.2 billion for research and community health programs. And Komen is pledging to invest another $2 billion during the next 10 years.

This year, Komen introduces new research programs called Promise Grants, which are worth millions of dollars and last for five years. They are designed to get scientists and doctors to work together in new ways to bring treatments out of the laboratory to patients as quickly as possible. Komen also is funding new and bigger grants to attract and retain young cancer researchers.

Moddelmog noted that research and awareness funding has helped ease suffering from breast cancer. "In the past 20 years, we've gone from a time when breast cancer was not even discussed, to a new era with higher survivor rates and less invasive treatments than existed even just a decade ago," Moddelmog said.

"Even so, we have so much more to do. Almost 200,000 women will be diagnosed with breast cancer in the U.S. this year and more than 40,000 women and men will die of this disease. That adds urgency to our mission to end breast cancer forever."

The Komen grants undergo a rigorous peer-review process by groups of laboratory scientists, clinicians and advocates. These grants fall into the following categories:

* Promise Grants: Large-scale grants, up to $7.5 million each during a five-year period, targeted to research that brings science to the bedside quicker than ever before. Komen will provide $35 million in Promise grants to seven, multi-year projects in 2008.

* Post-Doctoral Research: Grants of $60,000 per year to attract and retain promising young researchers nationwide and internationally. Forty-six scientists will share grant funding that totals $7.7 million over three years.

* Career Catalyst Research: Grants of $150,000 per year for three years to fill a critical gap in support and stimulate the transition from training to independence among promising cancer investigators. Total funding: $10.9 million to 26 researchers.

* Investigator Initiated Research: Grants of up to $200,000 per year for three years to explore new ideas and approaches leading to reductions in breast cancer mortality and/or the incidence within the decade. Total funding: $35.3 million for 60 grants.

* Affiliate Grants: Special grants co-funded by 15 Komen Affiliates to institutions in their hometowns or states.

In addition, Komen has directed $13 million to other cancer research organizations to fund collaborative projects. A complete list of the grants can be found on www.komen.org/grants

About Susan G. Komen for the Cure(R)

Nancy G. Brinker promised her dying sister, Susan G. Komen, she would do everything in her power to end breast cancer forever. In 1982, that promise became Susan G. Komen for the Cure and launched the global breast cancer movement. Today, Komen for the Cure is the world's largest grassroots network of breast cancer survivors and activists fighting to save lives, empower people, ensure quality care for all and energize science to find the cures. Thanks to events like the Komen Race for the Cure Series, we have invested more than $1.2 billion to fulfill our promise, becoming the largest source of nonprofit funds dedicated to the fight against breast cancer in the world. For more information about Susan G. Komen for the Cure, breast health or breast cancer, visit http://www.komen.org or call 1-877 GO KOMEN.

The following research and training grants being funded by Susan G. Komen for the Cure in 2008 address the biggest questions in breast cancer research, allowing us to begin to prevent breast cancer development, find cancers when they are most easily cured, and to bring more effective treatments to patients.

Research topic areas are noted for each grant, and descriptions of the focus and promise of research in these topic areas are described in the Research Topic Descriptions document available on http://www.komen.org. A pound sign (#) designates projects that are being co-funded by the local Komen Affiliate. And asterisk (*) indicates that contract negotiations have not been finalized.


                                          Total
                          Total Amount Institution  Total State   Principal

State Institution Awarded Dollars Dollars Investigator


 Australia  University of                                       Mark Smyth,
            Melbourne        $598,492                           Ph.D.*
 Australia  University of                                       Erik Thompson,
            Melbourne        $180,000     $778,492     $778,492 Ph.D.
   Belgium  Katholieke                                          Peter
            Universiteit                                        Carmeliet,
            Leuven-Vib       $576,000     $576,000     $576,000 M.D., Ph.D.*
    Canada  Samuel
            Lunenfeld
            Research
            Institute at
            Mount Sinai
            Hospital,
            University of                                       Pamela
            Toronto          $495,374     $495,374              Goodwin, M.D.*
    Canada  Sir Mortimer B.
            Davis - Jewish
            General
            Hospital, Lady
            Davis
            Institute for                                       Marc
            Medical                                             Tischkowitz,
            Research         $290,852     $290,852              M.D., Ph.D.
    Canada  The Hospital
            for Sick                                            Sean Egan,
            Children         $595,274     $595,274   $1,381,500 Ph.D.*
                                                                Giuseppe
    Italy   European                                            Viale, M.D.*
            Institute of                                        Olivia Pagani,
            Oncology       $3,929,682   $3,929,682   $3,929,682 MD
            Ecole
            Polytechnique
            Federale de                                         Melody Swartz,
Switzerland Lausanne         $150,000     $150,000     $150,000 Ph.D.
    AL      University of
            Alabama at                                          Elizabeth
            Birmingham       $120,000     $120,000     $120,000 Sztul, Ph.D.*
    CA      California
            Pacific                                             John Muschler,
            Medical Center   $180,000     $180,000              Ph.D.*
    CA      City of Hope
            Beckman
            Research                                            Shiuan Chen,
            Institute        $600,000     $600,000              Ph.D.
    CA      Lawrence
            Berkeley
            National                                            Mina Bissell,
            Laboratory       $118,322     $118,322              Ph.D.*
    CA      Stanford
            University,
            School of                                           David Feldman,
            Medicine         $599,999                           M.D.
    CA      Stanford
            University,
            School of                                           Robert
            Medicine         $180,000                           Carlson, M.D.
    CA      Stanford
            University,
            School of                                           James Ford,
            Medicine         $180,000                           Ph.D.
    CA      Stanford
            University,
            School of                                           James Ford,
            Medicine         $180,000   $1,139,999              Ph.D.
    CA      University of
            California at                                       Randall
            San Diego        $600,000                           Johnson, Ph.D.
    CA      University of                                       Marilyn
            California at                                       Farquhar,
            San Diego        $180,000                           Ph.D.
    CA      University of                                       Michael
            California at                                       Rosenfeld,
            San Diego        $180,000                           M.D.
    CA      University of
            California at                                       Michael Karin,
            San Diego        $180,000   $1,140,000              Ph.D.
    CA      University of
            California at                                       Elad Ziv,
            San Francisco    $596,228                           M.D.*
    CA      University of
            California at                                       Gerard Evan,
            San Francisco    $600,000                           Ph.D.*
    CA      University of
            California at                                       Andrei Goga,
            San Francisco    $600,000                           M.D., Ph.D.*
    CA      University of
            California at                                       Zena Werb,
            San Francisco    $180,000                           DVM, Ph.D.*
    CA      University of
            California at                                       Mark Moasser,
            San Francisco    $180,000                           Ph.D.*
                                                                Mark Moasser,
    CA      University of                                       M.D.*
            California at                                       James Wells,
            San Francisco  $1,000,000   $3,156,228              PhD
    CA      University of
            Southern                                            Peter Laird,
            California       $180,000                           Ph.D.*
    CA      University of
            Southern
            California
            (USC), Keck
            School of                                           Michael Kahn,
            Medicine         $600,000     $780,000   $7,114,549 Ph.D.
    CO      University of
            Colorado
            Health                                              Steven
            Sciences                                            Anderson,
            Center           $599,999     $599,999     $599,999 Ph.D.*
                                                                Nita Maihle,
    CT      Yale University  $180,000                           Ph.D.*
    CT      Yale
            University,                                         Joshua
            School of                                           VanHouten,
            Medicine         $450,000                           Ph.D.*
    CT      Yale
            University,
            School of                                           Patrick Sung,
            Medicine         $180,000     $810,000     $810,000 Ph.D.
    DC      Georgetown
            University,
            Lombardi
            Comprehensive                                       Priscilla
            Cancer Center    $180,000     $180,000     $180,000 Furth, M.D.
    FL      H. Lee Moffitt
            Cancer Center
            & Research                                          Geza Acs,
            Institute        $595,811     $595,811              M.D., Ph.D.
    FL      University of                                       Brian Law,
            Florida          $600,000     $600,000   $1,195,811 Ph.D.#
    IA      University of
            Iowa at Carver                                      Frederick
            College of                                          Domann,
            Medicine         $180,000     $180,000     $180,000 Ph.D.*#
    IL      Evanston
            Northwestern
            Healthcare
            Research                                            Toru Ouchi,
            Institute        $600,000     $600,000              Ph.D.
    IL      Loyola
            University,                                         Kimberly
            Chicago          $586,581     $586,581              Foreman, Ph.D.
    IL      Northwestern
            University,
            Feinberg
            School of                                           Ming Zhang,
            Medicine         $600,000     $600,000              Ph.D.
    IL      Southern
            Illinois
            University
            School of                                           Kounosuke
            Medicine         $177,975     $177,975              Watabe, Ph.D.
    IL      University of
            Illinois at                                         Rohit
            Champaign and                                       Bhargava,
            Urbana           $600,000     $600,000   $2,564,556 Ph.D.
    IN      Indiana
            University,
            School of                                           Hiromi Tanaka,
            Medicine         $450,000                           Ph.D.*
    IN      Indiana
            University,
            School of                                           David Gilley,
            Medicine         $600,000                           Ph.D.
    IN      Indiana
            University,
            School of                                           John Foley,
            Medicine         $463,499   $1,513,499   $1,513,499 Ph.D.*#
    KY      University of                                       Robert Stout,
            Louisville       $600,000                           Ph.D.
    KY      University of
            Louisville at
            School of                                           Carolyn
            Medicine         $600,000   $1,200,000   $1,200,000 Klinge, Ph.D.#
    MA      Boston
            University                                          Sam
            School of                                           Thiagalingam,
            Medicine         $600,000     $600,000              Ph.D.
    MA      Brigham and                                         Stephen
            Women's                                             Elledge,
            Hospital         $180,000     $180,000              Ph.D.*
    MA      Dana-Farber
            Cancer                                              Xiuwei Yang,
            Institute        $448,371                           Ph.D.
    MA      Dana-Farber                                         Piotr
            Cancer                                              Sicinski,
            Institute        $600,000                           M.D., Ph.D.*
    MA      Dana-Farber                                         Kornelia
            Cancer                                              Polyak, M.D.,
            Institute        $180,000                           Ph.D.
    MA      Dana-Farber
            Cancer                                              Myles Brown,
            Institute        $120,000                           Ph.D.
    MA      Dana-Farber                                         Geoffrey
            Cancer                                              Shapiro, M.D.,
            Institute        $120,000   $1,468,371              Ph.D.*
                                                                Marielle
    MA      Massachusetts                                       Scherrer-
            General                                             Crosbie, M.D.,
            Hospital         $600,000     $600,000              Ph.D.
    MA      Tufts
            University       $180,000     $180,000              Amy Yee, Ph.D.
    MA      Whitehead
            Institute for
            Biomedical                                          Harvey Lodish,
            Research         $180,000     $180,000   $3,208,371 Ph.D.
    MD      Johns Hopkins                                       Rachel
            University       $599,798                           Karchin, Ph.D.
    MD      Johns Hopkins                                       Robert Casero,
            University       $600,000                           Ph.D.
    MD      Johns Hopkins
            University,
            Kimmel Cancer                                       Nita Ahuja,
            Center           $573,030                           M.D.*
    MD      Johns Hopkins
            University,
            Kimmel Cancer                                       Vered Stearns,
            Center           $120,000                           M.D.*#
    MD      Johns Hopkins
            University,                                         Edward
            School of                                           Gabrielson,
            Medicine         $600,000                           Ph.D.*
    MD      Johns Hopkins
            University,                                         Giovanni
            School of                                           Parmigiani,
            Medicine         $573,750                           Ph.D.
    MD      Johns Hopkins
            University,
            School of                                           Cynthia
            Medicine         $180,000   $3,246,578              Zahnow, Ph.D.
    MD      University of
            Maryland at                                         Jeffrey
            Baltimore        $600,000                           Winkles, Ph.D.
    MD      University of
            Maryland at
            School of                                           Geoffrey
            Medicine         $450,001   $1,050,001   $4,296,579 Girnun, Ph.D.
    MI      Wayne State
            University,
            Karmanos
            Cancer                                              Guojun Wu,
            Institute        $450,000                           Ph.D.#
    MI      Wayne State
            University,
            Karmanos
            Cancer                                              Julie Boerner,
            Institute        $450,000     $900,000     $900,000 Ph.D.#
    MN      Mayo Clinic and
            Foundation,                                         Fergus Couch,
            Rochester        $600,000                           Ph.D.*
    MN      Mayo Clinic and
            Foundation,                                         Fergus Couch,
            Rochester        $180,000     $780,000              Ph.D.
    MN      University of                                       Michael
            Minnesota at                                        Grossmann,
            Twin Cities      $448,884                           Ph.D.
    MN      University of                                       Kathryn
            Minnesota at                                        Schwertfeger,
            Twin Cities      $450,000     $898,884   $1,678,884 Ph.D.
    MO      University of
            Missouri at                                         Edward Sauter,
            Columbia         $600,090     $600,090              M.D., Ph.D.*
    MO      Washington
            University at
            St. Louis,
            School of                                           Simon Powell,
            Medicine         $600,000                           M.D., Ph.D.*
    MO      Washington
            University at
            St. Louis,
            School of                                           Helen Piwnica-
            Medicine         $600,000                           Worms, Ph.D.
    MO      Washington
            University at
            St. Louis,
            School of                                           Loren Michel,
            Medicine         $600,000                           M.D.
    MO      Washington
            University in                                       Rebecca Aft,
            St. Louis        $600,000                           M.D., Ph.D.
    MO      Washington                                          William
            University in                                       Gillanders,
            St. Louis        $180,000   $2,580,000   $3,180,090 M.D.
    NC      Duke University                                     Michael Morse,
            Medical Center   $512,984                           M.D.*
    NC      Duke University
            Medical Center   $600,000                           Jun Zhu, Ph.D.
    NC      Duke University                                     Wei Chen,
            Medical Center   $600,000                           Ph.D.
    NC      Duke University                                     H. Kim Lyerly,
            Medical Center   $180,000                           Ph.D.
    NC      Duke
            University,
            School of                                           Gerard Blobe,
            Medicine         $180,000   $2,072,984              Ph.D.
    NC      University of                                       Rebecca
            North Carolina                                      Cleveland,
            at Chapel Hill   $341,156                           Ph.D.
    NC      University of
            North Carolina                                      Yue Xiong,
            at Chapel Hill   $600,000                           Ph.D.
    NC      University of
            North Carolina                                      Kathleen
            at Chapel Hill   $599,997                           Dorsey, Ph.D.
    NC      University of
            North Carolina                                      Channing Der,
            at Chapel Hill   $180,000   $1,721,153              Ph.D.#
    NC      Wake Forest
            University
            Health                                              Kazushi Inoue,
            Sciences         $180,000     $180,000   $3,974,137 M.D., Ph.D.
    NE      University of                                       Surinder
            Nebraska         $180,000                           Batra, Ph.D.
    NE      University of
            Nebraska                                            James Shull,
            Medical Center   $599,996     $779,996     $779,996 Ph.D.
    NJ      University of
            Medicine &
            Dentistry of
            New Jersey,
            Robert Wood
            Johnson                                             Ling Qin,
            Medical School   $450,000     $450,000     $450,000 Ph.D.#
    NY      Albany Medical                                      Jihe Zhao,
            College          $180,000     $180,000              M.D.,Ph.D.
    NY      Albert Einstein
            College of
            Medicine at
            Yeshiva                                             Nancy
            University       $180,000     $180,000              Carrasco, M.D.
    NY      Cornell
            University,                                         Richard
            Ithaca           $600,000                           Cerione, Ph.D.
    NY      Cornell
            University,
            Weill Medical                                       David Lyden,
            College          $600,000   $1,200,000              M.D., Ph.D.
                                                                Joseph
    NY      New York                                            Guttenplan,
            University       $600,000     $600,000              Ph.D.
    NY      Polytechnic
            Institute ,                                         Stavroula
            Brooklyn, NY     $450,000     $450,000              Sofou, Ph.D.#
    NY      Riverside
            Research                                            Sheikh Alam,
            Institute        $594,000     $594,000              Ph.D.
    NY      State
            University of
            New York at                                         Emily Chen,
            Stony Brook      $300,000                           Ph.D.
    NY      State
            University of
            New York at                                         Wei-Xing Zong,
            Stony Brook      $450,000     $750,000              Ph.D.
    NY      University of
            Rochester                                           Sabine
            School of                                           Brouxhon,
            Medicine         $299,872     $299,872   $4,253,872 M.D.#
    OH      Cleveland
            Clinic                                              Li-Xin Wang,
            Foundation       $449,447     $449,447              M.D., Ph.D.#
    OH      Ohio State
            University,
            College of                                          Huey-Jen Lin,
            Medicine         $450,000     $450,000              Ph.D.*
    OH      University of                                       Shao-Chun
            Cincinnati       $600,000     $600,000   $1,499,447 Wang, Ph.D.*#
    OK      University of
            Oklahoma
            Health
            Sciences                                            Wei-Qun Ding,
            Center           $597,500     $597,500     $597,500 Ph.D.
    PA      Fox Chase                                           Andrew Godwin,
            Cancer Center    $180,000     $180,000              Ph.D.
    PA      Pennsylvania
            State
            University
            College of                                          David Feith,
            Medicine         $600,000                           Ph.D.
    PA      Pennsylvania
            State                                               Andrea Manni,
            University                                          M.D.
            College of                                          Karam El-
            Medicine       $7,498,495   $8,098,495              Bayoumy, Ph.D.
    PA      Thomas
            Jefferson                                           Philippe
            University       $450,000                           Frank, Ph.D.
    PA      Thomas
            Jefferson                                           Jean-Francois
            University       $450,001                           Jasmin, Ph.D.
    PA      Thomas                                              Agnieszka
            Jefferson                                           Witkiewicz,
            University       $450,000                           M.D.
    PA      Thomas
            Jefferson                                           Hallgeir Rui,
            University       $180,000   $1,530,001              M.D., Ph.D.
    PA      University of
            Pennsylvania
            School of
            Medicine         $448,837                           Lin Li, Ph.D.
    PA      University of
            Pennsylvania                                        Andrew
            School of                                           Maidment,
            Medicine         $120,000     $568,837              Ph.D.
    PA      University of                                       Margarita
            Pittsburgh       $588,018     $588,018  $10,965,351 Zuley, M.D.
    RI      Brown                                               Susan Gerbi,
            University       $600,000     $600,000     $600,000 Ph.D.*
    SC      Clemson                                             Ya-Ping Sun,
            University       $180,000     $180,000     $180,000 Ph.D.*#
    TN      Vanderbilt
            University                                          David Cortez,
            Medical Center   $600,000     $600,000     $600,000 Ph.D.
    TX      Baylor College                                      Debananda
            of Medicine      $180,000                           Pati, Ph.D.
                                                                Powel Brown,
                                                                M.D., Ph.D.*
    TX      Baylor College                                      Gordon Mills,
            of Medicine    $7,138,690   $7,318,690              M.D., Ph.D.
    TX      M.D. Anderson
            Cancer Center,                                      Christine
            University of                                       Stellrecht,
            Texas            $450,000                           Ph.D.
    TX      M.D. Anderson
            Cancer Center,                                      Bulent
            University of                                       Ozpolat, M.D.,
            Texas            $406,579                           Ph.D.
    TX      M.D. Anderson
            Cancer Center,
            University of                                       Kapil Mehta,
            Texas            $582,064                           Ph.D.
    TX      M.D. Anderson
            Cancer Center,
            University of                                       Gordon Mills,
            Texas            $600,000                           M.D., Ph.D.
    TX      M.D. Anderson
            Cancer Center,
            University of                                       Yun Wu, M.D.,
            Texas            $600,000                           Ph.D.
    TX      M.D. Anderson
            Cancer Center,                                      Laszlo
            University of                                       Radvanyi,
            Texas            $180,000                           Ph.D.
    TX      M.D. Anderson
            Cancer Center,
            University of                                       Shiaw-Yih Lin,
            Texas            $120,000                           Ph.D.
    TX      M.D. Anderson
            Cancer Center,
            University of                                       Kelly Hunt,
            Texas            $180,000                           Ph.D.
                                                                Sai-ching
    TX      M.D. Anderson                                       Yeung, M.D.,
            Cancer Center,                                      Ph.D.*
            University of                                       Mong-Hong Lee,
            Texas          $7,234,072                           Ph.D.
                                                                Fredika
                                                                Robertson,
    TX      M.D. Anderson                                       Ph.D.
            Cancer Center,                                      Massimo
            University of                                       Cristofanilli,
            Texas          $7,500,000                           M.D.
    TX      M.D. Anderson                                       William
            Cancer Center,                                      Symmans, M.D.*
            University of                                       Lajos Pusztai,
            Texas            $998,688  $18,851,403              M.D., Ph.D.
    TX      University of
            North Texas at
            Health Science                                      Fang Fang
            Center, Fort                                        Zhang, M.D.,
            Worth            $243,202     $243,202              Ph.D.
    TX      University of
            Texas at
            Health Science                                      Charles
            Center at                                           Streckfus,
            Houston          $429,634                           DDS*
    TX      University of
            Texas at
            Health Science
            Center at                                           Mikhail
            Houston          $180,000     $609,634              Kolonin, Ph.D.
    TX      University of
            Texas at
            Medical
            Branch,                                             Binhua Zhou,
            Galveston        $600,000     $600,000  $27,622,929 M.D., Ph.D.
    UT      University of
            Utah at
            Huntsman
            Cancer                                              Alana Welm,
            Institute        $450,000                           Ph.D.
    UT      University of
            Utah at
            Huntsman
            Cancer                                              Richard
            Institute        $528,629     $978,629     $978,629 Kerber, Ph.D.
    VA      University of
            Virginia at
            School of                                           Sarah Aiyar,
            Medicine         $449,997                           Ph.D.*
    VA      University of
            Virginia at
            School of                                           Theresa Guise,
            Medicine         $120,000     $569,997     $569,997 Ph.D.*
    WA      University of
            Washington at                                       Mary Claire
            Seattle          $600,000     $600,000     $600,000 King, Ph.D.
Website: http://www.komen.org//




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